ORNL researchers are working with the US Department of Energy (DOE), industry, and academia to understand complex biological systems to enable development of industrially relevant bioproducts that create new bioenergy solutions and support improved human health. ORNL is leading the way in advancing the use of plants and microbes for next-generation bioproducts and biofuels. Our techniques incorporate high-performance computing, artificial intelligence (AI), and genomic algorithms to uncover networks of genes contributing to complex traits that are critical in bioenergy, human health, and other focus areas. ORNL scientists have full access to the Spallation Neutron Source, allowing them to explore and uncover structures and interactions inside cells. They also examine the way proteins fold and how the cycling of disordered proteins between various 3D shapes affects gene expression. ORNL expertise leads to key innovations for biomanufacturing, synthetic biology, agriculture, bioenergy, and treatment of human diseases.